| MATCH | TIME | LOCATION |
|---|---|---|
CF Montréal  vs  Atlanta United | Stade Saputo | |
Vancouver Whitecaps  vs  Portland Timbers | BC Place Stadium | |
Inter Miami  vs  TBC | Inter Miami CF Stadium | |
LA Galaxy  vs  Colorado Rapids | Dignity Health Sports Park | |
Orlando City  vs  Charlotte | Orlando City Stadium | |
Los Angeles FC  vs TBC | Banc of California Stadium | |
Cincinnati  vs  New York City | ||
Seattle Sounders  vs  Houston Dynamo | CenturyLink Field | |
Columbus Crew  vs  New York RB | MAPFRE Stadium | |
Real Salt Lake  vs  Minnesota United | Rio Tinto Stadium | |
New York City  vs  Cincinnati | Yankee Stadium | |
Charlotte  vs  Orlando City | Bank of America Stadium (Charlotte, North Carolina) |
| No. | Team | Pts | W | L | D | P |
|---|---|---|---|---|---|---|
| 1 | Inter Miami | 74 | 22 | 4 | 8 | 79:49 |
| 2 | Columbus Crew | 66 | 19 | 6 | 9 | 72:40 |
| 3 | Cincinnati | 59 | 18 | 11 | 5 | 58:48 |
| 4 | Orlando City | 52 | 15 | 12 | 7 | 59:50 |
| 5 | Charlotte | 51 | 14 | 11 | 9 | 46:37 |
| 6 | New York City | 50 | 14 | 12 | 8 | 54:49 |
| 7 |  New York RB | 47 | 11 | 9 | 14 | 55:50 |
| 8 | CF Montréal | 43 | 11 | 13 | 10 | 48:64 |
| 9 |  Atlanta United | 40 | 10 | 14 | 10 | 46:49 |
| 10 |  DC United | 40 | 10 | 14 | 10 | 52:70 |
| 11 |  Toronto | 37 | 11 | 19 | 4 | 40:61 |
| 12 |  Philadelphia Union | 37 | 9 | 15 | 10 | 62:55 |
| 13 |  Nashville SC | 36 | 9 | 16 | 9 | 38:54 |
| 14 |  New England | 31 | 9 | 21 | 4 | 37:74 |
| 15 |  Chicago Fire | 30 | 7 | 18 | 9 | 40:62 |